Flare Up & 6th Stem Cell Birthday

I have been having a bad flare with diarrhea like 15 times a day. It has been going on a few months but Sunday I saw blood so I knew I needed to make an appointment.

I'm being tested for c diff. Ugh, it's been 6 years since I have had c diff and I so hope this isn't it. It isn't the type of thing you look forward to.

My blood work shows elevated inflammation markers and low hemoglobin.

On that note, today is my re-birthday! 6 years ago today was day 0 and I received my sister's stem cells and started my healing journey! I have had my ups and downs but I'm not dying anymore so yay! Lol

I'll keep you posted on my lab results!

Donate Your Stool?? Healthy People Only

You can earn $13,000 a year selling your poop

By Rachel Feltman January 29 

You can donate blood, plasma, eggs, and sperm. Why not poop? Yes, your feces are perhaps your greatest untapped monetary resource. Thanks to a nonprofit organization called OpenBiome, you can cash in to the tune of $13,000 a year -- and save lives while you're at it.

Since 2013, OpenBiome has been processing and shipping loads of it all over the country. The frozen stool is administered to patients who are very sick with infections of a bacteria called C. difficile. The bacteria can cause extreme gastrointestinal distress, leaving some sufferers housebound. Antibiotics often help, but sometimes the bacteria rears back as soon as treatment stops. That leads to a miserable, continuous course of antibiotics.

By introducing healthy fecal matter into the gut of a patient (by way of endoscopy, nasal tubes, or swallowed capsules) doctors can abolish C. difficile for good. Finding a donor is tough business, and some patients grow so desperate that they treat themselves with fecal matter from friends and family. That's what happened to a friend of OpenBiome's founders, inspiring them to open up the first nationwide bank. So far they've shipped about 2,000 treatments to 185 hospitals around the country.

And yes, they pay for healthy poop: $40 a sample, with a $50 bonus if you come in five days a week. That's $250 for a week of donations, or $13,000 a year.

Save your stools, save the world. (OpenBiome)
There's a catch: You don't just have to be healthy. You have to be really healthy. OpenBiome's donation procedure may be as easy as your standard bowel movement, but the selection process makes giving blood look like a walk in the park.

"It's harder to become a donor than it is to get into MIT," joked co-founder Mark Smith (who would know, as he got his PhD in microbiology there). Of the 1,000 or so potential donors who've expressed interest on his Web site over the past two years, only about 4 percent have passed the extensive medical questioning and stool testing.

The screening process can cost up to $5,000 -- so when someone makes it through, Smith and his co-founders hold on tight.

"We get most of our donors to come in three or four times a week, which is pretty awesome," Smith said. "You're usually helping three or four patients out with each sample, and we keep track of that and let you know."

The precious poo awaits its destiny at -80 celsius. (OpenBiome)
Fellow co-founder Carolyn Edelstein agrees that the donors are usually in it for more than the money.

"Everyone thinks it's great that they're making money doing such an easy thing," Edelstein said, "But they also love to hear us say, 'Look, your poop just helped this lady who's been sick for nine years go to her daughter's graduation.'"

Who are these valiant donors, these chosen few? Since they have to come into the Medford, Mass. office, lots of them are Tufts University students. And plenty are recruited from the gym next door.

"It's great to have a healthy contingent of regular gym goers right there," Smith said.

OpenBiome has sent out more than 2,000 transplant specimens. (OpenBiome)
For now fecal matter transplants really only have one use: treating recurring C. difficile. But OpenBiome is providing its samples to a number of trials exploring other uses.

Scientists know that the gut microbiomes of people with obesity, inflammatory bowel disease, and even autism are different from those without. But just because there are gut flora associated with these conditions doesn't mean that getting rid of them can get rid of their symptoms, and it certainly isn't a given that fecal transplants will be the miracle solution they are for  C. difficile.

"There's a lot of promise in other conditions," Smith said, "But also a lot of hype. Treating C. difficile is a bit less sexy, but that's the one area where we know this works." However, he's excited to see where the "crazy frontier" of microbiome engineering will take us.

And in the meantime, Smith is always happy to find more potential donors.

"I never thought that after getting my PhD I'd start mailing poop around," he said, "But here I am."

 

Fecal Transplant Study As A Possible Cure

Inflammatory Bowel Disease 'Cured' With Fecal Transplant

January 22, 2015 5:06 PM
By Jessica Berman

Inflammatory bowel diseases, such as Crohn’s disease and ulcerative colitis, are extremely painful and can lead to colorectal cancer. Now, researchers have effectively cured the conditions in mice, offering hope for human sufferers of so-called IBDs.

Waste material from healthy people is rich in helpful bacteria. When transferred to the digestive tracts of sick individuals, in whom there is an overgrowth of bad bacteria, the fecal matter helps restore the balance of healthy flora.

Some cutting-edge doctors have used so-called fecal transplants to treat severe bacterial infections, including Clostridium difficile or C. diff, which releases toxins as it grows, attacking the lining of the intestines.

Scientists also have found the transplants appear to reverse autoimmune diseases of the bowel.

Crohn’s disease and ulcerative colitis, also known as inflammatory bowel disease or IBD, are life-long disorders that cause severe diarrhea, painful cramps and bleeding.

According to June Round, a professor of medicine at the University of Utah, such diseases are becoming increasingly common around the world, as more and more people eat a low-fiber, high-fat Western diet.

Round also blames the widespread use of antibiotics.

“So, I think a lot about the microbes that naturally reside in our bodies. And antibiotics can not distinguish between what is good and what is bad," she said. "They kind of wipe-out everything. So, there is a very clear-cut correlation between when Western civilization started using the antibiotics and the increased incidence of a lot of these autoimmune diseases.”

Currently, treatments for these conditions are supportive, designed only to ease the symptoms. So, the idea of a potential cure for IBD is very appealing.

In experiments with mice with inflammatory bowel disease, Round and her team found that fecal transplant restored the healthy balance of intestinal flora, returning the intestine to near normal.

But the notion of transferring fecal material from one person to another -- and in the case of mice, through a tube into the stomach -- makes many people say "yuck." So Round said researchers are now trying to identify the helpful bacteria in human waste so they can be put into pill form.

“You know, right now we have to do fecal transplantation because the [bacterial] communities are so complex, and we just do not know what organisms are doing the good thing," she said. "So, we just kind of put it all in there and hope for the best. So, there is no way of getting around it right now, but hopefully in the future there will be.”

The work is published in the journal Cell Host and Microbe.