Saturday, November 8, 2014

Complications Associated with Crohn's

Complications
By Mayo Clinic Staff

Crohn's disease may lead to one or more of the following complications:

Inflammation. Inflammation may be confined to the bowel wall, which can lead to scarring and narrowing (stenosis), or may spread through the bowel wall (fistula).Bowel obstruction. Crohn's disease affects the thickness of the intestinal wall. Over time, parts of the bowel can thicken and narrow, which may block the flow of digestive contents. You may require surgery to remove the diseased portion of your bowel.Ulcers. Chronic inflammation can lead to open sores (ulcers) anywhere in your digestive tract, including your mouth and anus, and in the genital area (perineum).

Fistulas. Sometimes ulcers can extend completely through the intestinal wall, creating a fistula — an abnormal connection between different body parts. Fistulas can develop between your intestine and skin, or between your intestine and another organ. Fistulas near or around the anal area (perianal) are the most common kind.

When fistulas develop in the abdomen, food may bypass areas of the bowel that are necessary for absorption. Fistulas may occur between loops of bowel, into the bladder or vagina, or out through the skin, causing continuous drainage of bowel contents to your skin.

In some cases, a fistula may become infected and form an abscess, which can be life-threatening if not treated.

Anal fissure. This is a small tear in the tissue that lines the anus or in the skin around the anus where infections can occur. It's often associated with painful bowel movements and may lead to a perianal fistula.Malnutrition. Diarrhea, abdominal pain and cramping may make it difficult for you to eat or for your intestine to absorb enough nutrients to keep you nourished. It's also common to develop anemia due to low iron or vitamin B-12 caused by the disease.Colon cancer. Having Crohn's disease that affects your colon increases your risk of colon cancer. General colon cancer screening guidelines for people without Crohn's disease call for a colonoscopy every 10 years beginning at age 50. Ask your doctor whether you need to have this test done sooner and more frequently.Other health problems. Crohn's disease can cause problems in other parts of the body. Among these problems are anemia, osteoporosis, and gallbladder or liver disease.

Medication risks. Certain Crohn's disease drugs that act by blocking functions of the immune system are associated with a small risk of developing cancers such as lymphoma and skin cancers. They also increase risk of infection.

Corticosteroids can be associated with a risk of osteoporosis, bone fractures, cataracts, glaucoma, diabetes and high blood pressure, among others. Work with your doctor to determine risks and benefits of medications.

Hookworm Treatment For Crohn's Disease


Hook Worms as a Treatment for Crohn's Disease
Written by Stephanie Faris | Published on March 2, 2012
Medically Reviewed by George Krucik, MD
A hook worm grows in the small intestine of humans, cats, and dogs, growing and putting its host at risk for infection. Why would someone volunteer to be infected with hook worms? Patients undergo helminthic therapy to cure or control certain diseases, likeCrohn’s.

Helminthic Therapy

Helminthic therapy involves infecting a patient with worms from the helminth family, including hook worms and whipworms. Most of the time, the patient will receive an injection of the worm’s eggs via inoculation. This therapy is not only used to treat Crohn’s disease, but alsomultiple sclerosis, asthma, and inflammatory bowel disease (IBD), among others.

Hook worms can sometimes cause itching and blistering in the patient, but this side effect is mostly just discomfort. Cutaneous larva migrans is a more concerning side effect, causing a “creeping eruption” that both reddens the skin and causes it to rise. The good news about hook worms is they generally don’t go much deeper than the skin, which helps prevent them from doing further damage.

Hook Worms & Crohn's

In patients with diseases like Crohn’s, hook worms are thought to lessen the body’s autoimmune response to antigens, which in turn reduces infection in the gastrointestinal tract. Some researchers believe that because today’s children aren’t as exposed to infectious diseases as children were in past generations, the incidence of conditions such as Crohn’s in adults has increased. Treatments such as hook worm therapy are now necessary to restore the body’s natural autoimmune balance.

One major problem for Crohn’s patients looking for treatment is that often they will have to travel far to be infected with hook worms. Currently, only one clinic in Tijuana, Mexico, is providing hook worm treatment for Crohn’s. However, as more research is done, there may be an increase in the availability of hook worm therapy.

Helminthic Therapy in the U.S.

Currently, a company called Ovamed is working on getting the necessary approvals for helminthic therapy. In recent years, a San Diego company, Asphelia Pharmaceuticals, began working with Ovamed on researching various forms of helminthictherapy. Asphelia noted that patients infected with hook worms and other helminths tended to be less likely to get diseases such as multiple sclerosis and Crohn’s. The key, Asphelia says, is to find a helminth that has minimal side effects with multiple advantages. Hook worms may be the very helminth researchers are searching for. Aside from the skin issues mentioned above, hook worms can also cause diarrhea, anemia, and weight loss. However, these side effects are generally present in more severe infestations.

Hook Worm Therapy Research

Hook worms are also being researched by a University of Nottingham researcher in England. While hook worms are dangerous in the tropics where infestations are common, scientist David Pritchard had no problems among his patients in controlled experiments, he says. Because the hook worms are instituted in such small numbers, the risks of anemia and infection are smaller, so patients are able to reap benefits without concern of major side effects.

In his tests, Dr. Pritchard found that his subjects showed lower amounts of inflammation in the intestines, which was measured by testing the T-cells of study participants. Those participating in the study also noticed that their allergy symptoms began disappearing. As word spread of the work Dr. Pritchard was doing, he was able to extend his research to other allergy sufferers and he soon became known as the first helminthic therapy researcher to actually infect his subjects with hook worms.

The long-term goal of Dr. Pritchard and other researchers is to track down the reason hook worms and other helminths are so effective, to possibly develop less invasive ways of treating patients suffering from immune system disorders. While many patients may cringe at the thought of being infected with hook worms, the fact that they work in treating patients with asthma, allergies, and other issues should not be minimized.

Side Effects of Hook Worm Therapy

Over time, hook worms can cause side effects that can be more dangerous, including increased risk for anemia. Protein deficiency can also develop, leading to an impairment of mental functioning  and stunting physical growth in some patients. Medications are available to offset these side effects and patients undergoing hook worm therapy may be prescribed iron supplements if anemia is present.

Friday, November 7, 2014

Bell's Palsy Information

What is Bell's Palsy?

Bell's palsy is a form of temporary facial paralysis resulting from damage or trauma to the facial nerves. The facial nerve-also called the 7th cranial nerve-travels through a narrow, bony canal (called the Fallopian canal) in the skull, beneath the ear, to the muscles on each side of the face. For most of its journey, the nerve is encased in this bony shell.

Each facial nerve directs the muscles on one side of the face, including those that control eye blinking and closing, and facial expressions such as smiling and frowning. Additionally, the facial nerve carries nerve impulses to the lacrimal or tear glands, the saliva glands, and the muscles of a small bone in the middle of the ear called the stapes. The facial nerve also transmits taste sensations from the tongue.

When Bell's palsy occurs, the function of the facial nerve is disrupted, causing an interruption in the messages the brain sends to the facial muscles. This interruption results in facial weakness or paralysis.

Bell's palsy is named for Sir Charles Bell, a 19th century Scottish surgeon who was the first to describe the condition. The disorder, which is not related to stroke, is the most common cause of facial paralysis. Generally, Bell's palsy affects only one of the paired facial nerves and one side of the face, however, in rare cases, it can affect both sides.

What are the Symptoms?

Because the facial nerve has so many functions and is so complex, damage to the nerve or a disruption in its function can lead to many problems. Symptoms of Bell's palsy can vary from person to person and range in severity from mild weakness to total paralysis.  These symptoms may include twitching, weakness, or paralysis on one or rarely both sides of the face.  Other symptoms may include drooping of the eyelid and corner of the mouth, drooling, dryness of the eye or mouth, impairment of taste, and excessive tearing in one eye. Most often these symptoms, which usually begin suddenly and reach their peak within 48 hours, lead to significant facial distortion.

Other symptoms may include pain or discomfort around the jaw and behind the ear, ringing in one or both ears, headache, loss of taste, hypersensitivity to sound on the affected side, impaired speech, dizziness, and difficulty eating or drinking.

What Causes Bell's Palsy?

Bell's palsy occurs when the nerve that controls the facial muscles is swollen, inflamed, or compressed, resulting in facial weakness or paralysis. Exactly what causes this damage, however, is unknown.

Most scientists believe that a viral infection such as viral meningitis or the common cold sore virus—herpes simplex—causes the disorder. They believe that the facial nerve swells and becomes inflamed in reaction to the infection, causing pressure within the Fallopian canal and leading to ischemia (the restriction of blood and oxygen to the nerve cells).  In some mild cases (where recovery is rapid), there is damage only to the myelin sheath of the nerve.  The myelin sheath is the fatty covering-which acts as an insulator-on nerve fibers in the brain.

The disorder has also been associated with influenza or a flu-like illness, headaches, chronic middle ear infection, high blood pressure, diabetes, sarcoidosis, tumors, Lyme disease, and trauma such as skull fracture or facial injury.

Who Gets it?

Bell's palsy afflicts approximately 40,000 Americans each year.  It affects men and women equally and can occur at any age, but it is less common before age 15 or after age 60.  It disproportionately attacks people who have diabetes or upper respiratory ailments such as the flu or a cold.

How is it Diagnosed?

A diagnosis of Bell's palsy is made based on clinical presentation -- including a distorted facial appearance and the inability to move muscles on the affected side of the face -- and by ruling out other possible causes of facial paralysis. There is no specific laboratory test to confirm diagnosis of the disorder.

Generally, a physician will examine the individual for upper and lower facial weakness.  In most cases this weakness is limited to one side of the face or occasionally isolated to the forehead, eyelid, or mouth.  A test called electromyography (EMG) can confirm the presence of nerve damage and determine the severity and the extent of nerve involvement.  Blood tests can sometimes be helpful in diagnosing other concurrent problems such as diabetes and certain infections.  A magnetic resonance imaging (MRI) or computed tomography (CT) scan can eliminate other structural causes of pressure on the facial nerve.

How is it Treated?

Bell's palsy affects each individual differently.  Some cases are mild and do not require treatment as the symptoms usually subside on their own within 2 weeks.  For others, treatment may include medications and other therapeutic options.  If an obvious source is found to cause Bell's palsy (e.g., infection), directed treatment can be beneficial.  

Recent studies have shown that steroids such as the steroidprednisone -- used to reduce inflammation and swelling --are effective in treating Bell's palsy.  Other drugs such as acyclovir -- used to fight viral herpes infections -- may also have some benefit in shortening the course of the disease.  Analgesics such as aspirin, acetaminophen, or ibuprofen may relieve pain.  Because of possible drug interactions, individuals taking prescription medicines should always talk to their doctors before taking any over-the-counter drugs.

Another important factor in treatment is eye protection. Bell's palsy can interrupt the eyelid's natural blinking ability, leaving the eye exposed to irritation and drying.  Therefore, keeping the eye moist and protecting the eye from debris and injury, especially at night, is important.  Lubricating eye drops, such as artificial tears or eye ointments or gels, and eye patches are also effective.

Physical therapy to stimulate the facial nerve and help maintain muscle tone may be beneficial to some individuals.  Facial massage and exercises may help prevent permanent contractures (shrinkage or shortening of muscles) of the paralyzed muscles before recovery takes place. Moist heat applied to the affected side of the face may help reduce pain.

Other therapies that may be useful for some individuals include relaxation techniques, acupuncture, electrical stimulation, biofeedback training, and vitamin therapy (including vitamin B12, B6, and zinc), which may help restore nerve function.

In general, decompression surgery for Bell's palsy -- to relieve pressure on the nerve -- is controversial and is seldom recommended.  On rare occasions, cosmetic or reconstructive surgery may be needed to reduce deformities and correct some damage such as an eyelid that will not fully close or a crooked smile.

What is the Prognosis?

The prognosis for individuals with Bell's palsy is generally very good.  The extent of nerve damage determines the extent of recovery.  Improvement is gradual and recovery times vary.  With or without treatment, most individuals begin to get better within 2 weeks after the initial onset of symptoms and most recover completely, returning to normal function within 3 to 6 months.  For some, however, the symptoms may last longer.  In a few cases, the symptoms may never completely disappear.  In rare cases, the disorder may recur, either on the same or the opposite side of the face.

What Research is Being Done?

Within the Federal Government, the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), is responsible for supporting and conducting research on brain and nervous system disorders, including Bell's palsy. The NINDS conducts research in its laboratories at the NIH, in Bethesda, Maryland, and supports research through grants to major medical institutions across the country.

The NINDS conducts and supports an extensive research program of basic science to increase understanding of how the nervous system works and what causes the system to sometimes go awry, leading to dysfunction. Part of this research program focuses on learning more about the circumstances that lead to nerve damage and the conditions that cause injuries and damage to nerves. Knowledge gained from this research may help scientists find the definitive cause of Bell's palsy, leading to the discovery of new effective treatments for the disorder. Other NINDS-supported research is aimed at developing methods to repair damaged nerves and restore full use and strength to injured areas, and finding ways to prevent nerve damage and injuries from occurring.

 

"Bell's Palsy Fact Sheet," NINDS. Publication date April 2003.

NIH Publication No. 03-5114

NINDS health-related material is provided for information purposes only and does not necessarily represent endorsement by or an official position of the National Institute of Neurological Disorders and Stroke or any other Federal agency. Advice on the treatment or care of an individual patient should be obtained through consultation with a physician who has examined that patient or is familiar with that patient's medical history.

All NINDS-prepared information is in the public domain and may be freely copied. Credit to the NINDS or the NIH is appreciated.

Oncologist Appointment

I saw my oncologist yesterday.  Here's what he said:
-lymphocytes are even higher
-white blood cells are up
- and of course not to go to urgent care anymore because they don't have my history and the bells palsy needed to be seen by my primary care doctor or the er since im post transplant. .awesome.

Wednesday, November 5, 2014

Coping Mechanisms

We all need a way to cope with this disease. A lot of people don't understand what we go through and I encourage everyone to find their outlet.  Mine is poetry and drawing. Now im going to show you a few of my sketches.  But I want your feedback. .should I post them on this blog or start a different one for them? I want to know if it's more beneficial for you to keep this blog totally crohn's related. Thanks guys!

Sunday, November 2, 2014

Birthday Activities Part II

Yep im officially 28! And so glad to be here another year!

Bells Palsy

I woke up yesterday with half of my face paralyzed with bells palsy. .fun. great way to end my birthday lol now im in toms of steroids (like I want more chipmunk cheeks..) and antivirals.  fortunately it's fairly subtle but blowing out my birthday candles wasnt easy lol and this constant tearing in my right eye is driving me insane.  Then top it off, my grandmother's cat of over 20 years passed away today and we had to help her bury him. And my fiance's uncle passed away today too. Not a fun day for sure.